To become a model cleft center of excellence in cleft care that all cleft centers in Pakistan will strive for, Cleft Hospital Gujrat founded its research department in Dec, 2015. The main aim of this department is to improve cleft care for patients by doing research into causes, prevention and treatment of cleft lip and palate.


A number of observational and case-control studies are being done by the department since its inception. Some of these have been published in known journals. A number of studies are currently in the process of data analysis. However, a lot of research still needs to be done in the area of cleft in Pakistan as demographic studies done in the past are outdated and little or no genetic level research on finding the causative agents of cleft is being done.
  We have currently established our own facility to initiate clinical research at genetic level on cleft. Our future objective is to collaborate with other cleft care centers around the world to identify key gene variants or loci involved in the development of cleft that are specific to our population.

Ongoing Studies

  • Maternal risk factors and the development of orofacial cleft
  • Cleft and ear issues
  • Quality of life in cleft families
  • Feeding problems in cleft babies
  • Effects of pre-surgical molding techniques

    Future Plan

    Identification of genes and loci involved in the etiology of cleft lip &/or cleft palate in Pakistani population.


    Best Presentation Award for “A single stage cleft rhinoplasty technique for primary unilateral cleft lip and palate- The Gujrat Technique”


  • Anthony HB, Ayisha A, Mairaj KA, Emanuela T& Peter JT. Association Between Cleft Lip and/or Cleft Palate and Family History of Cancer:A Case-Control Study. Annals of Plastic Surgery, 2018.
  • Mairaj Ahmed, YunfengXue and AyishaAyub (2017). Strategies to Optimize Global Cleft Care, Designing Strategies for Cleft Lip and Palate Care, Dr. MazenAlmasri (Ed.), InTech, DOI:10.5772/67186. Available from:
  • Riaz A, Farah N, Hussnain H, Ayisha A &Ijaz B. Demographic and social factors in relation with occurrence of orofacial defects, Medical Forum Monthly,June 2017; pg 10-13.
  • Javed UR, Mushahid A, Hashim Z, Habib UR, Ijaz B &Aqeel S. evaluation of the role of the “Tadpole” island flap in the repair of post operative palatal fistulae, PAFMJ, 2016; 66(3), pg 390-94.
  • Poster Presentation

  • A poster presented on 3/13/2017 at the New York Regional Society of Plastic Surgeons, 2017 Annual Resident’s Night: Maternal Tobacco Exposure and Risk of Orofacial Clefts in the Child
  • The Society for Epidemiologic Research 50th Annual Meeting : Maternal Tobacco Exposure and Risk of Orofacial Clefts in the Child
  • Mount Sinai’s Child Health Research Day
  • The American Society of Plastic Surgeons meeting
  • 2nd International symposium on Advances in Molecular Biology of Plants and Health Sciences
  • Information

    Cleft Hospital Pakistan is a world class facility for complete treatment of Cleft Lip and Cleft Palate Patients.Cleft Hospital is a Non-Profit Organization Dedicated to Improve the Quality of Life of Infants, Children and Adults with Cleft Lip and Palate or Craniofacial Conditions.

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